Vasiliki T. Chioti

Oct 25, 2023 | pubs.acs.org | Vasiliki T. Chioti |Kenzie A. Clark |Jack Ganley |Esther Han

DUF692 multinuclear iron oxygenases (MNIOs) are an emerging family of tailoring enzymes involved in the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs). Three members, MbnB, TglH, and ChrH, have been characterized to date and shown to catalyze unusual and complex transformations.

Oct 25, 2023 | dx.doi.org | Vasiliki T. Chioti |Kenzie A. Clark |Jack Ganley |Esther Han

DUF692 multinuclear iron oxygenases (MNIOs) are an emerging family of tailoring enzymes involved in the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs). Three members, MbnB, TglH, and ChrH, have been characterized to date and shown to catalyze unusual and complex transformations.

Apr 1, 2023 | dx.doi.org | Nicole R. Hauser |Clarissa C. Forneris |Kendra A. Ireland |Vasiliki T. Chioti

The emergence of multidrug-resistant pathogens poses a threat to public health and requires new antimicrobial agents. As the archetypal glycopeptide antibiotic (GPA) used against drug-resistant Gram-positive pathogens, vancomycin provides a promising starting point. Peripheral alterations to the vancomycin scaffold have enabled the development of new GPAs. However, modifying the core remains challenging due to the size and complexity of this compound family.