Vasso Terzidou

May 15, 2024 | jme.bioscientifica.com | Abigail Walker |sung kim |Holly A Parkin |Vasso Terzidou

Keywords: EP2; GPCR; prostaglandin; traffickingIntroductionEP2 is a prostaglandin E2 (PGE2) receptor and one of four G protein-coupled receptors (GPCRs) activated by PGE2 (EP1-4). EP2 is widely expressed, with high expression in vascular endothelium, human intestine, lung, kidney, uterus, and cerebral cortex (Woodward et al. 2011), and is implicated in numerous pathological disorders via both under and over-activation, including epilepsy, endometriosis and cancer.