Veronica Lattanzi

Oct 11, 2024 | pubs.rsc.org | Kalyani Sanagavarapu |Georg Meisl |Katja Bernfur |Veronica Lattanzi

Serine phosphorylation mimics of Aβ form distinct, non-cross-seeding fibril morphs The self-assembly of amyloid-β peptide (Aβ) into fibrils and oligomers is linked to Alzheimer’s disease (AD). Fibrillar aggregates in AD patient’s brains contain several post-translational modifications, including phosphorylation at positions 8 and 26. These play a key role in modifying the aggregation propensity of Aβ, yet how they affect the mechanism of aggregation is only poorly understood.