Victor S. Lelyveld

Oct 26, 2023 | science.org | Brian Wood |Eugenia Saini |Shinichi Sunami |Victor S. Lelyveld

Editor’s summaryDNA polymerases, like most enzymes, are specific for their native substrates, deoxyribonucleotides, and have carefully tuned active site chemistry that can be challenging to adapt. Lelyveld et al. performed time-resolved x-ray crystallography on a DNA polymerase variant that accepts a 3′-amino sugar, catalyzing the formation of phosphoramidate linkages instead of the natural phosphodiester bonds.