Vikash Kansal

Mar 6, 2024 | onlinelibrary.wiley.com | Vikash Kansal |Nicole C. Schmitt

Preclinical models are invaluable for studies of head and neck cancer. There is growing interest in the use of orthotopic syngeneic models, wherein cell lines are injected into the oral cavity of immunocompetent mice. In this brief report, we describe injection of mouse oral cancer 1 (MOC1) cells into the buccal mucosa and illustrate the tumor growth pattern, lymph node response, and changes in the tumor immune microenvironment over time.

Jan 14, 2024 | biorxiv.org | Vikash Kansal |Brendan Kinney |Nicole C. Schmitt

AbstractBackground: Preclinical models are invaluable for studies on the pathogenesis and treatment of head and neck cancer. In recent years, there has been growing interest in the use of orthotopic syngeneic models, wherein head and neck cancer cell lines are injected into the oral cavity of immunocompetent mice. However, few such orthotopic models have been described in detail.