Vinayak Bhandari

Oct 31, 2024 | digitalcommons.library.tmc.edu | Dan J. Woodcock |Ruxandra Teslo |Vinayak Bhandari |Andreas Gruber

AbstractThe development of cancer is an evolutionary process involving the sequential acquisition of genetic alterations that disrupt normal biological processes, enabling tumor cells to rapidly proliferate and eventually invade and metastasize to other tissues. We investigated the genomic evolution of prostate cancer through the application of three separate classification methods, each designed to investigate a different aspect of tumor evolution.

Feb 29, 2024 | cell.com | Dan J. Woodcock |Ruxandra Teslo |Vinayak Bhandari |Andreas Gruber

Highlights • Analysis of genomic data from localized prostate cancer reveals divergent evolution • The shift away from the canonical trajectory is characterized by AR dysregulation • Tumors can be classified into evotypes according to evolutionary trajectory • The evotype model unifies many previous molecular observations Summary The development of cancer is an evolutionary process involving the sequential acquisition of genetic alterations that disrupt normal biological processes, enabling...