Vincent Tse

May 22, 2024 | jneurosci.org | Vincent Tse

In several neurodegenerative disorders, glutamate—the primary excitatory neurotransmitter—spills over from the synaptic cleft and drives excessive activation of extrasynaptic NMDA receptors (NMDARs), leading to excitotoxicity (Parsons and Raymond, 2014; Andersen et al., 2021). Therefore, some researchers have attempted to develop treatments for neurodegenerative disorders using general NMDAR blockers to attenuate this excitotoxicity, but without success.

May 13, 2024 | nature.com | MIchelle Cahill |Michelle K. Cahill |Max Collard |Vincent Tse |Roberto Etchenique |Christoph Kirst

Correction to: Nature https://doi.org/10.1038/s41586-024-07311-5 Published online 17 April 2024In the version of this article initially published, an erroneous grey hexagon appeared next to the bottom label in Fig. 3a. It has now been removed from the HTML and PDF versions of the article.

Apr 17, 2024 | nature.com | MIchelle Cahill |Michelle K. Cahill |Max Collard |Vincent Tse |Roberto Etchenique |Christoph Kirst

AbstractAstrocytes, the most abundant non-neuronal cell type in the mammalian brain, are crucial circuit components that respond to and modulate neuronal activity through calcium (Ca2+) signalling1,2,3,4,5,6,7. Astrocyte Ca2+ activity is highly heterogeneous and occurs across multiple spatiotemporal scales—from fast, subcellular activity3,4 to slow, synchronized activity across connected astrocyte networks8,9,10—to influence many processes5,7,11.

Dec 4, 2023 | biorxiv.org | MIchelle Cahill |Michelle K. Cahill |Max Collard |Vincent Tse |Michael E. Reitman

AbstractAstrocytes—the most abundant non-neuronal cell type in the mammalian brain—are crucial circuit components that respond to and modulate neuronal activity via calcium (Ca2+) signaling. Astrocyte Ca2+ activity is highly heterogeneous and occurs across multiple spatiotemporal scales: from fast, subcellular activity to slow, synchronized activity that travels across connected astrocyte networks. Furthermore, astrocyte network activity has been shown to influence a wide range of processes.

Oct 4, 2023 | wsp.com | Vincent Tse

map markerGlobal|October 5, 2023 Reading Time :6 minsVincent Tse spent the first 20 years of his career as a mechanical engineer, developing the air conditioning systems for some of the world’s tallest buildings. Then at the age of 56 he switched to vertical transportation. At the top of his career, admired by architects, clients and colleagues alike, he remains grounded, modest and full of humility.  Could you describe your career path?