Vinoba Bhave

Mar 15, 2024 | cell.com | Vinit Kumar |Agricultural Bioengineering |Markham College |Vinoba Bhave

Highlights Fks1 is a unique enzyme that makes β-1,3-glucan, a key cell wall component. Blocking Fks1 kills fungi by damaging their cell wall. Fks1 enhances fungal virulence and host infection by contributing to pathogenesis and immune response, while β-1,3-glucan is a biomarker for fungal infections. Fks1 is a promising target for new antifungal drugs. Studies on echinocandins and ibrexafungerp have identified their binding sites and action mechanisms on Fks1.