Vissarion Efthymiou

Jan 7, 2025 | cell.com | Xinxin Yu |Shiuhwei Chen |Jan-Bernd Funcke |Leon G. Straub |Valentina Pirro |Margo P. Emont | +15 more

KeywordsGIP receptoradipose tissueobesityweight lossenergy expenditureSERCA pathwayIntroductionThe prevalence of obesity has substantially increased. The World Health Organization recognizes obesity as a worldwide epidemic and a major disease of the 21st century, with >4 million people dying in 2017.1 Obesity is characterized as excessive fat accumulation that presents a health risk, which results from a dysregulation in energy homeostasis, i.e., caloric intake exceeding energy expenditure.

Jul 13, 2023 | nature.com | Vissarion Efthymiou |Wenfei Sun |Hua Dong

AbstractThe current obesity epidemic and high prevalence of metabolic diseases necessitate efficacious and safe treatments. Brown adipose tissue in this context is a promising target with the potential to increase energy expenditure, however no pharmacological treatments activating brown adipose tissue are currently available. Here, we identify AXL receptor tyrosine kinase as a regulator of adipose function.