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Jan 24, 2025 | 
link.springer.com | San Raffaele |Reggio Emilia |Vita-Salute San Raffaele
AbstractTo determine whether extending anti-CGRP mAb treatment beyond 3 years influences migraine course, we analyzed migraine frequency during the first month of treatment discontinuation following three 12-month treatment cycles (Ts). This multicenter, prospective, real-world study enrolled 212 patients with high-frequency episodic migraine (HFEM) or chronic migraine (CM) who completed three consecutive Ts of subcutaneous anti-CGRP mAbs.
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Jan 18, 2025 | 
academic.oup.com | Vita-Salute San Raffaele
Intestinal ultrasound (IUS) is emerging as a valuable tool to assess treatment response in inflammatory bowel disease (IBD) clinical trials. This study details how IUS defines response and remission to evaluate treatment efficacy in IBD patients. We conducted a comprehensive search of studies from 1984 to 31 March 2024, focusing on IUS use in assessing treatment efficacy in IBD. A total of 51 studies were included: 31 on Crohn's disease (CD), 12 on ulcerative colitis (UC) and 8 on IBD.
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Jan 7, 2025 | 
academic.oup.com | Vita-Salute San Raffaele |De Bonis
Jacopo Lin, Francesco Maisano, Michele De Bonis, Giant left atrial appendage aneurysm: a source of multiple thrombotic events despite medical therapy, European Heart Journal, 2025;, ehae935, https://doi.org/10.1093/eurheartj/ehae935 Close You do not currently have access to this article.
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Nov 29, 2024 | 
academic.oup.com | Vita-Salute San Raffaele
The ability to predict the pathology spreading in patients with frontotemporal dementia (FTD) is crucial for early diagnosis and targeted interventions. This study examined the relationship between network vulnerability and longitudinal atrophy progression in FTD patients, using Network Diffusion Model (NDM) of pathology spread.
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Nov 19, 2024 | 00726-6/fulltext&sz=64)
thelancet.com | Angelo Roberto Raccagni |Vita-Salute San Raffaele |Sara Diotallevi |Elena Bruzzesi
Bacterial sexually transmitted infections (STIs) are a considerable burden among people with HIV and users of HIV pre-exposure prophylaxis (PrEP).1–3 Doxycycline post-exposure prophylaxis (DoxyPEP) is a pharmacological intervention, the efficacy of which in reducing bacterial STIs, particularly syphilis and chlamydia, has been confirmed in several clinical trials.4–9 In this study, we aimed to evaluate the uptake of DoxyPEP among men who have sex with men (MSM) in Milan, Italy, its...
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Nov 18, 2024 | 
molecular-cancer.biomedcentral.com | Vita-Salute San Raffaele
ReferencesHol L, van Leerdam ME, van Ballegooijen M, et al. Screening for colorectal cancer: randomised trial comparing guaiac-based and immunochemical faecal occult blood testing and flexible sigmoidoscopy. Gut. 2010;59(1):62–8. Article PubMed Google Scholar Shaukat A, Mongin SJ, Geisser MS, et al. Long-term mortality after screening for colorectal cancer. N Engl J Med. 2013;369(12):1106–14. Article PubMed Google Scholar Kubisch CH, Crispin A, Mansmann U, et al.
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Sep 29, 2024 | 
link.springer.com | Vita-Salute San Raffaele
AbstractRecently, the α-synuclein origin and connectome model described two types of Parkinson’s disease: “brain-first” and “body-first” subtypes. We aimed to investigate the role of periodic limb movements during sleep (PLMS) in identifying these subtypes starting from a prodromal stage of α-synucleinopathies. 191 patients with isolated REM sleep behavior disorder (iRBD) underwent video-polysomnography (vPSG), questionnaires, clinical interview, and neuropsychological battery.
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Sep 23, 2024 | 02606-x/fulltext?rss=yes&sz=64)
europeanurology.com | Vita-Salute San Raffaele |Ribeirão Preto
Get full text accessLog in, subscribe or purchase for full access. ReferencesPanebianco, V. ∙ Narumi, Y. ∙ Altun, E. ... Multiparametric magnetic resonance imaging for bladder cancer: development of VI-RADS (Vesical Imaging-Reporting and Data System)Eur Urol. 2018; 74:294-3062. Safiri, S. ∙ Kolahi, A.A. ∙ Naghavi, M.
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Sep 19, 2024 | 
academic.oup.com | Vita-Salute San Raffaele
Gastric cancer is a malignant tumor that ranks third in cancer-related deaths worldwide. Early-stage gastric cancer can often be effectively managed through surgical resection. However, the majority of cases are diagnosed in advanced stages, where outcomes with conventional radiotherapy and chemotherapy remain unsatisfactory. Immunotherapy offers a novel approach to treating molecularly heterogeneous gastric cancer by modifying the immunosuppressive tumor microenvironment.
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Sep 18, 2024 | 
link.springer.com | Vita-Salute San Raffaele
AbstractFatigue is commonly observed in pediatric multiple sclerosis (pedMS) patients, but its underlying mechanisms remain largely unexplored. We evaluated whether resting-state (RS) functional connectivity (FC) abnormalities in monoaminergic networks contributed to explain fatigue in pedMS. Fifty-five pedMS and twenty-three matched healthy controls (HC) underwent clinical and RS functional MRI assessment. Patients with Fatigue Severity Scale (FSS) score ≥ 4 were classified as fatigued (F).
