
Vivian Wagner
Writer at Freelance
Articles
-
1 month ago |
strangehorizons.com | Vivian Wagner |M.C. Childs |Jenny Hamilton |Em Setzer
Sky Full of Elephants by Cebo Campbell is an innovative science fiction novel that explores race, identity, and trauma in new and unexpected ways. It follows its characters after all the white people in the United States abruptly commit suicide, in what the novel refers to simply as “the event.” Those left behind after the event attempt to rebuild the world and their communities, and the novel describes these efforts on both personal and cultural levels.
-
Nov 15, 2024 |
nature.com | Vivian Wagner |Ronell Bologna-Molina |Rogerio Moraes Castilho |Alan Roger Santos-Silva |Vanessa Rodrigues Velho |Tuany Rafaeli Schmidt | +9 more
The present investigation aimed to assess the safety of photobiomodulation (PBM) on the oral carcinogenesis process induced by 4NQO, focusing on cell proliferation and apoptosis. Sixty-six Wistar rats received systemic 4NQO for 12 (n = 33) and 20 weeks (n = 33), divided into Control group, PBM 0.3 J, and PBM 1 J. Applications for PBM occurred three times a week. At weeks 12 and 20, the animals were euthanized. The immunoreactivity for anti-ROS1 and anti-p53 antibodies was also assessed. Statistical analysis was assessed by multiple t-tests, Kruskal-Wallis, and Spearman’s correlation. At 12 weeks, PBM 1 J group had nodular lesions, distinct from control and PBM 0.3 J groups (p = 0.005). At 20 weeks, nodular lesions were common in control and PBM 0.3 J groups. Histopathological characteristics did not significantly differ between groups at 12 (p = 0.30) and 20 weeks (p = 0.58). Epithelial dysplasia (n = 21) was common at 12 weeks. After 20 weeks, most of the cases revealed squamous cell carcinoma (n = 24). No differences were observed in the immunostaining of p53 and ROS1 among the control and experimental groups and there was no correlation of these proteins with clinicopathological data. During the carcinogenesis process, the PBM did not modify the development of oral lesions and the expression of proliferative and apoptosis proteins.
Try JournoFinder For Free
Search and contact over 1M+ journalist profiles, browse 100M+ articles, and unlock powerful PR tools.
Start Your 7-Day Free Trial →