Vytautas Iesmantavicius

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A comprehensive Schizosaccharomyces pombe atlas of physical transcription factor interactions with proteins and chromatin

1 month ago | cell.com | Merle Skribbe |Charlotte Soneson |Michael Stadler |Michaela Schwaiger |Vytautas Iesmantavicius |Daniel B. Hess | +4 more

Keywordstranscription factor interactionshigh occupancy target (HOT) regionsNattou complexTFexplorerTF binding motifsfission yeast librarybinuclear zinc cluster TFsimmunoprecipitation-mass spectrometryChIP-sequencingIntroductionTranscription factors (TFs) regulate gene expression by binding to DNA in a sequence-specific manner and recruiting effector proteins. Despite their pivotal role, the regulatory targets and modes of action of many TFs remain unknown.

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