Wai Shing Tang

Oct 22, 2024 | biorxiv.org | Wai Shing Tang |Aaditya V Rangan |Pilar Cossio |Jeff Soules

AbstractExtracting conformational heterogeneity from cryo-electron microscopy (cryo-EM) images is particularly challenging for flexible biomolecules, where traditional 3D classification approaches often fail. Over the past few decades, advancements in experimental and computational techniques have been made to tackle this challenge, especially Bayesian-based approaches that provide physically interpretable insights into cryo-EM heterogeneity.