Wanlapa Roobsoong

Nov 13, 2023 | biorxiv.org | Ling Wei |Wanlapa Roobsoong |Elizabeth KK Glennon |Veronica I Primavera

AbstractUpon transmission to the liver, Plasmodium vivax parasites form replicating schizonts, which continue to initiate blood-stage infection, or dormant hypnozoites that reactivate weeks to months after initial infection. P. vivax phenotypes in the field vary significantly, including the ratio of schizonts to hypnozoites formed and the frequency and timing of relapse. Evidence suggests that both parasite genetics and environmental factors underly this heterogeneity.