Wei Feng Ma

Sep 14, 2024 | biorxiv.org | Caitlin Bell |Richard A. Baylis |Nicolas Lopez |Nicolás López |Wei Feng Ma

AbstractBackground: Smooth muscle cell (SMC) plasticity and phenotypic switching play prominent roles in the pathogenesis of multiple diseases, but their role in tumorigenesis is unknown. We investigated whether and how SMC diversity and plasticity plays a role in tumor angiogenesis and the tumor microenvironment. Methods and Results: We use SMC-specific lineage-tracing mouse models and single cell RNA sequencing to observe the phenotypic diversity of SMCs participating in tumor vascularization.