Wei Tian

1 month ago | nature.com | Fang-Yuan Yang |Wei Tian |Rong-Rong Xie |Ran Sun |Xiao-Rong Zhu |Zi-Yang Wang | +1 more

Diabetic macular edema (DME), a sight-threatening retinopathy, is a leading cause of vision loss in persons with diabetes mellitus. Despite strict control of systemic risk factors, a fraction of patients with diabetes developed DME, suggesting the existence of other potential pathogenic factors underlying DME. This study aimed to investigate the plasma metabotype of patients with DME and to identify novel metabolite markers for DME. Biomarkers identified from this study will provide scientific insight and new strategies for the early diagnosis and intervention of DME. To match clinical parameters between case and control subjects, patients with DME (DME, n = 30) or those with diabetes but without DME (Control, n = 30) were assigned to the present case-control study. Distinct metabolite profiles of serum were examined using liquid chromatography-mass spectrometry (LC-MS). A total of 190 distinct metabolites between DME and Control groups were identified (VIP > 1, Fold Change > 1.5 or < 0.667, and P < 0.05). The distinct metabolites between DME and Control groups were enriched in 4 KEGG pathways, namely, Glutamate Metabolism, Carnitine Synthesis, Oxidation of Branched Chain Fatty Acids, and Phytanic Acid Peroxisomal Oxidation. Finally, 4 metabolites were selected as candidate biomarkers for DME, namely, 5-Phospho-beta-D-ribosylamine, Succinic acid, Ascorbyl glucoside, and Glutathione disulfide. The area under the curve for these biomarkers were 0.693, 0.772, 0.762, and 0.771, respectively. This study suggested that impairment in the metabolism and 4 potential metabolites were identified as metabolic dysregulation associated with DME, which might provide insights into potential new pathogenic pathways for DME. 5-Phospho-beta-D-ribosylamine was first identified as a novel metabolite marker, with no previous reports linking it to diabetes or DME. This discovery may offer valuable insights into potential new pathogenic pathways associated with DME.

Dec 30, 2024 | nature.com | Wei Tian

AbstractMetastable supramolecular polymerization under kinetic control has recently been recognized as a closer way to biosystem than thermodynamic process. While impressive works on metastable supramolecular systems have been reported, the library of available non-covalent driving modes is still small and a simple yet versatile solution is highly desirable to design for easily regulating the energy landscapes of metastable aggregation.

Dec 9, 2024 | mdpi.com | Wei Tian |Hao Yue Zhu |Yongwei Wang |Xianda Liu

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Dec 5, 2024 | onlinelibrary.wiley.com | Wei Tian |Lixin Li

• , , , et al., “ Diversity of Alleles Encoding HLA-B40: Relative Frequencies in United States Populations and Description of Five Novel Alleles ,” Human Immunology , no. ( ): – . • , , , and , “ Contribution of Ancient Human Remains Analysis to the Understanding of the Variability in HLA-B Gene Variants in Relation to the Diagnosis of Spondyloarthropathies ,” Journal of Autoimmunity ( ): – .

Nov 28, 2024 | mdpi.com | Wei Tian |Jose Herrera |José Herrera |Adrian M. Hucal |Pierre-Christof Ascherl

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.