Weikang Ma

Mar 22, 2024 | nature.com | Anthony L Hessel |Rachel Sadler |Weikang Ma |Wolfgang A. Linke

AbstractMuscle contraction is produced via the interaction of myofilaments and is regulated so that muscle performance matches demand. Myosin-binding protein C (MyBP-C) is a long and flexible protein that is tightly bound to the thick filament at its C-terminal end (MyBP-CC8C10), but may be loosely bound at its middle- and N-terminal end (MyBP-CC1C7) to myosin heads and/or the thin filament.