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Wenjun Xia

Featured in: Favicon wiley.com Favicon mdpi.com Favicon cell.com Favicon hindawi.com Favicon onlinelibrary.wiley.com

Articles

  • p53 promotes antiviral innate immunity by driving hexosamine metabolism

    Jan 31, 2024 | cell.com | Wenjun Xia |Peng Jiang

    Highlights•Loss of p53 impairs antiviral innate immunity•p53 drives HBP and protein O-GlcNAcylation following VSV infection•UBXN1 O-GlcNAcylation promotes TBK1-IRF3-IFN-β antiviral signaling•HBP activation is essential for p53-mediated antiviral immune responsesSummaryThe tumor suppressor p53 controls cell fate decisions and prevents malignant transformation, but its functions in antiviral immunity remain unclear.

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