William Dion

3 weeks ago | biorxiv.org | Elizabeth S. Anaya |William Dion |Pradip Saha |Aaron Cox

AbstractWhite adipose tissue (WAT) meets the energetic demands required for estrous cycle regularity, ovulation, and reproductive success in women. Here, we report WAT loss and subsequent female-specific compensatory beige fat recruitment impact metabolic and reproductive outcomes in mice. Female mice that undergo progressive lipoatrophy ('fat-less') displayed disrupted estrous cycles, reduced ovarian reserve, and subfertility.