William Kelly

1 month ago | bedfordtoday.co.uk | William Kelly

Thursday, 17th April, meeting 7.30pm. Valerie Vile is a passionate volunteer at RSPB Dungeness in Kent. She will tell us about the management, ecology and fascinating history of the reserve. (Brief meeting description e.g. from programme) Finishing by 9.30pm, with refreshment break. All facilities at ground level with parking on site. Suitable for all. RSPB membership not essential. Entrance: Adults £3 (cash/cheque only), Under 18's FREE.

2 months ago | bedfordtoday.co.uk | William Kelly

Watch more of our videos on ShotsTV.com and on Freeview 262 or Freely 565Visit Shots! nowMeeting 7.30pm, finishing by 9.30pm on Thursday 20th FebruaryBiddenham Village Hall, Nodders Way (off Main Road opposite the Three Tuns Pub), Biddenham, Bedford, MK40 4BJ'RSPB Nene Washes' This evening speaker Peter Beckenham, Warden at RSPB Nene Washes, will talk to us about this important reserve, one of the few remaining areas of washland in the UK, and the many birds that are now found there.

Aug 7, 2024 | nature.com | William Kelly |Virginia Kaklamani |Renu Pandey |Stefano Tiziani |John Floyd |Gangadhara R. Sareddy | +10 more

Sacituzumab Govitecan (SG) is an antibody-drug conjugate that has demonstrated efficacy in patients with TROP-2 expressing epithelial cancers. In a xenograft model of intracranial breast cancer, SG inhibited tumor growth and increased mouse survival. We conducted a prospective window-of-opportunity trial (NCT03995706) at the University of Texas Health Science Center at San Antonio to examine the intra-tumoral concentrations and intracranial activity of SG in patients undergoing craniotomy for breast cancer with brain metastases (BCBM) or recurrent glioblastoma (rGBM). We enrolled 25 patients aged ≥18 years diagnosed with BCBM and rGBM to receive a single intravenous dose of SG at 10 mg/kg given one day before resection and continued on days 1 and 8 of 21-day cycles following recovery. The PFS was 8 months and 2 months for BCBM and rGBM cohorts, respectively. The OS was 35.2 months and 9.5 months, respectively. Grade≥3 AE included neutropenia (28%), hypokalemia (8%), seizure (8%), thromboembolic event (8%), urinary tract infection (8%) and muscle weakness of the lower limb (8%). In post-surgical tissue, the median total SN-38 was 249.8 ng/g for BCBM and 104.5 ng/g for rGBM, thus fulfilling the primary endpoint. Biomarker analysis suggests delivery of payload by direct release at target site and that hypoxic changes do not drive indirect release. Secondary endpoint of OS was 35.2 months for the BCBM cohort and 9.5 months for rGBM. Non-planned exploratory endpoint of ORR was 38% for BCBM and 29%, respectively. Exploratory endpoint of Trop-2 expression was observed in 100% of BCBM and 78% of rGBM tumors. In conclusion, SG was found to be well tolerated with adequate penetration into intracranial tumors and promising preliminary activity within the CNS. Trial Registration: Trial (NCT03995706) enrolled at Clinical Trials.gov as Neuro/Sacituzumab Govitecan/Breast Brain Metastasis/Glioblastoma/Ph 0: https://clinicaltrials.gov/study/NCT03995706?cond=NCT03995706 . Sacituzumab Govitecan, TROP-2 targeted antibody drug conjugate, is effective for the treatment of breast cancer, but its potential utility for the treatment of breast cancer brain metastasis and recurrent glioblastoma is unclear. Here, the authors present a window-of-opportunity phase 0 trial reporting the central nervous system penetrance and intracranial efficacy of Sacituzumab Govitecan.

Jul 31, 2023 | palmbeachcivic.org | William Kelly

Inflation is expected to drive the cost of burying all overhead utility lines on the island upward by about $13 million, town officials say. An existing $2 million shortfall to meet construction costs is expected to grow by $11 million once bids are returned for the final three phases of the work, according to a town estimate. The town plans to cover the escalating costs by digging deeper into annual surpluses generated by the lucrative Town Marina.

Jan 9, 2023 | caia.org | William Kelly