William Young

Nov 13, 2024 | nature.com | William Young |Nay Aung |Luis Lopes |Perry Elliott |Petros Syrris |Roberto Barriales-Villa | +3 more

AbstractHeart shape captures variation in cardiac structure beyond traditional phenotypes of mass and volume. Although observational studies have demonstrated associations with cardiometabolic risk factors and diseases, its genetic basis is less understood. We utilised cardiovascular magnetic resonance images from 45,683 UK Biobank participants to construct a heart shape atlas from bi-ventricular end-diastolic surface mesh models through principal component (PC) analysis.