Won Dong Lee

Sep 17, 2024 | nature.com | Khanh V. Doan |Won Dong Lee |Sarmistha Mukherjee |Gabriel K. Adzika |Ryan B. Gaspar |Corey Holman | +3 more

AbstractNicotinamide adenine dinucleotide (NAD+) is an essential co-factor in metabolic reactions and co-substrate for signaling enzymes. Failing human hearts display decreased expression of the major NAD+ biosynthetic enzyme nicotinamide phosphoribosyltransferase (Nampt) and lower NAD+ levels, and supplementation with NAD+ precursors is protective in preclinical models.