Xiaoli Meng

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TSC22 domain family member 3 links natural killer cells to CD8+ T cell-mediated drug hypersensitivity - Signal Transduction and Targeted Therapy

1 week ago | nature.com | Zhenzhen Wang |Joshua Gardner |Xiaoli Meng

AbstractSevere cutaneous adverse drug reactions (SCARs) are life-threatening diseases, which are associated with human leukocyte antigen (HLA) risk variants. However, the low positive predictive values of HLA variants suggest additional factors influence disease susceptibility. Using dapsone hypersensitivity syndrome (DHS) as a paradigm for SCARs, we show that the DHS patients harbor a sex-related global reduction in blood NK cells, contributing to the higher incidence of reactions in females.

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