Xiaona Du

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Insights into Human Epileptogenesis with Proteomic Profiling

Jan 5, 2024 | biorxiv.org | Hailin Zhang |Wenling Li |Xiaona Du |Najing Zhou

AbstractEpilepsy affects millions globally, and drug-resistant epilepsy remains a challenge. Molecular mechanisms underlying epilepsy remain elusive. Protein profiling through proteomics offers insight into biomarkers and therapeutic targets. Human brain tissue from epilepsy surgeries was analyzed using data-independent acquisition (DIA) proteomics. Samples were categorized into Core (epileptogenic focus), Border (marginal excision tissue), and Nonepileptic control groups.

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