Xiaoping Tang

Nov 14, 2023 | nature.com | Jingrong Shi |Zheng Zhang |Liguo Zhang |Xiaoping Tang

AbstractThe underlying mechanism of chronic hepatitis B virus (HBV) functional cure by interferon (IFN), especially in patients with low HBsAg and/or young ages, is still unresolved due to the lack of surrogate models. Here, we generate a type I interferon receptor humanized mouse (huIFNAR mouse) through a CRISPR/Cas9-based knock-in strategy.