Xiaoxin Yan

Jan 8, 2025 | nature.com | Mohammad Haeri |Xiang Zhou |Lindong Jiang |Yi-Ping Phoebe Chen |Xiaoxin Yan |Russell H. Swerdlow | +1 more

AbstractAging increases the risk for Alzheimer’s disease (AD), driving pathological changes like amyloid-β (Aβ) buildup, inflammation, and oxidative stress, especially in the prefrontal cortex (PFC). We present the first subcellular-resolution spatial transcriptome atlas of the human prefrontal cortex (PFC), generated with Stereo-seq from six male AD cases at varying neuropathological stages and six age-matched male controls.