Xiaoyu Li

1 week ago | onlinelibrary.wiley.com | Binghua Li |Xiaoyu Li |Xian Tang |Jia Wang

Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description prot26826-sup-0001-Tables.zipZip archive, 9.9 MB Data S1. Supporting Information. References 1, , , and , “Strategies for Fighting Pandemic Virus Infections: Integration of Virology and Drug Delivery,” Journal of Controlled Release: Official Journal of the Controlled Release Society 343 (2022): 361–378.

2 weeks ago | associationofanaesthetists-publications.onlinelibrary.wiley.com | Xiaoyu Li |Bo Lu

The multicentre trial by Fang et al. is the first controlled trial assessing both the efficacy and safety of remimazolam in children [1], providing useful data for paediatric sedation practice. However, we wish to explore a pharmacokinetic observation regarding the pharmacokinetic-temporal relationship between drug administration and loss of consciousness. While the Methods specify 60-s administration for both drugs, median loss of consciousness occurred at 45 s (remimazolam) and 25 s (propofol).

1 month ago | arxiv.org | Xiaoyu Li |Yingyu Liang |Zhenmei Shi |Zhao Song

1 month ago | arxiv.org | Xiaoyu Li |Yingyu Liang |Jiangxuan Long |Zhenmei Shi

Today Hugging Face is TRIPLING your donation to arXiv with a 2:1 match! Give today to keep science open for all.

1 month ago | nature.com | Yuenan Zhou |Xushen Xiong |Xiaohua Shen |Xiaoyu Li

AbstractThe U1 small nuclear ribonucleoprotein (snRNP) has an essential role in initiating spliceosome assembly, yet the mechanism underlying its synergy with other splicing regulators for efficient spliceosome assembly remains elusive. Here we identify zinc finger protein 207 (ZFP207) as a key regulator of U1 snRNP function that substantially promotes spliceosome assembly. Acute depletion of ZFP207 results in a series of molecular phenotypes indicative of U1 snRNP dysregulation.