Xiaoyuan Lin

Nov 17, 2023 | nature.com | Weiwei Xue |Yang Luo |Xiaoyuan Lin

AbstractInterferon-gamma (IFN-γ) signaling is necessary for the proinflammatory activation of macrophages but IFN-γ-independent pathways, for which the initiating stimuli and downstream mechanisms are lesser known, also contribute. Here we identify, by high-content screening, SEPTIN2 (SEPT2) as a negative regulation of IFN-γ-independent macrophage autoactivation.