Xijia Dai

Jan 7, 2025 | cell.com | Lintao Song |Yushu Hou |Da Xu |Xijia Dai |Jianya Luo |Yi Liu | +18 more

Keywords FXR FGF4 bile acid homeostasis FGFR4-LRH-1 pathway cholestasis Introduction Bile acids (BAs) are vital for the digestion and absorption of lipophilic nutrients and also act as signaling molecules to regulate metabolic and energy homeostasis.1,2 Disruption in BA homeostasis or associated signaling pathways can lead to cholestasis, hepatobiliary damage, and metabolic disorders.3,4 BA homeostasis is maintained in part through negative feedback mechanisms and spatiotemporally controlled...