Xin Zhou

Aug 14, 2024 | nature.com | Xin Zhou |Chuchu Wang |Daniel Hornburg |Xiaotao Shen |Michael Snyder |Si Wu | +1 more

Aging is a complex process associated with nearly all diseases. Understanding the molecular changes underlying aging and identifying therapeutic targets for aging-related diseases are crucial for increasing healthspan. Although many studies have explored linear changes during aging, the prevalence of aging-related diseases and mortality risk accelerates after specific time points, indicating the importance of studying nonlinear molecular changes. In this study, we performed comprehensive multi-omics profiling on a longitudinal human cohort of 108 participants, aged between 25 years and 75 years. The participants resided in California, United States, and were tracked for a median period of 1.7 years, with a maximum follow-up duration of 6.8 years. The analysis revealed consistent nonlinear patterns in molecular markers of aging, with substantial dysregulation occurring at two major periods occurring at approximately 44 years and 60 years of chronological age. Distinct molecules and functional pathways associated with these periods were also identified, such as immune regulation and carbohydrate metabolism that shifted during the 60-year transition and cardiovascular disease, lipid and alcohol metabolism changes at the 40-year transition. Overall, this research demonstrates that functions and risks of aging-related diseases change nonlinearly across the human lifespan and provides insights into the molecular and biological pathways involved in these changes. Understanding the molecular changes underlying aging is important for developing biomarkers and healthy aging interventions. In this study, the authors used comprehensive multi-omics data to reveal nonlinear molecular profiles across chronological ages, highlighting two substantial variations observed around ages 40 and 60, which are linked to increased disease risks.

Jul 2, 2024 | scmp.com | Xin Zhou

OpenAI has fired a warning shot by blocking developers from mainland China and Hong Kong, showing the new reality of an increasingly divided world in AI.

Nov 8, 2023 | scmp.com | Xin Zhou

Alibaba CEO Eddie Wu reaffirms AI commitment, aims to turn e-commerce empire into ‘open tech platform’ Alibaba Group Holding, the e-commerce giant founded by Jack Ma that changed the way Chinese consumers shop, is remaking itself as an “open technology platform”, riding on a wave of rapid artificial intelligence (AI) innovation, new CEO Eddie Wu Yongming said on Wednesday.

Nov 7, 2023 | scmp.com | Xin Zhou

ByteDance’s virtual reality unit Pico pushes new round of job cuts in restructuring move amid falling demand for headsets ByteDance-owned virtual reality (VR) headset maker Pico is conducting a new round of job cuts in line with a restructuring, according to people familiar with the matter, as its sales in mainland China and overseas markets struggle this year.

Nov 6, 2023 | scmp.com | Xin Zhou

China’s anti-espionage ministry broke its silence to declare war against investors who “short” China’s financial markets via speech or acts. In an article published by China’s Ministry of State Security on its newly created social media account, the spy agency said financial security was part of overall national security and that it would go after those who “short” China with intentions to cause havoc in the financial market.