Xinshun Gu

Jul 6, 2023 | onlinelibrary.wiley.com | Xueyan Chen |Xiaofei Zhang |Kerang Xie |Xinshun Gu

RESEARCH ARTICLE Xueyan Chen nd Kerang Xie contributed equally to this study. Abstract Doxorubicin (DOX), an effective and broad-spectrum anthracycline antibiotic, is widely used in the treatment of numerous malignancies. However, dose-dependent cardiotoxicity limits the clinical application of DOX, and the molecular mechanisms are still unknown.