Xionglue Wang

3 weeks ago | biorxiv.org | Xionglue Wang |Jing Li |Zhichao Liu |Longfei Wang

AbstractCoronavirus nsp15 is an endoribonuclease that limits the accumulation of viral dsRNA in cytosol and plays a crucial role in the evasion of host immunity. Here, we show that Co2+ or Ni2+ potently activates nsp15 of human and animal coronaviruses, including SARS-CoV-2, SARS-CoV, MERS-CoV, HCoV-229E, MHV-A59, and PEDV. Whereas Zn2+ strongly inhibits nsp15 of these coronaviruses.