Xiudong Lei

Sep 4, 2024 | digitalcommons.library.tmc.edu | Caitlin Bell |Xiudong Lei |Allen Haas |Richard A. Baylis

BACKGROUND: Cardiovascular disease (CVD) and cancer share several risk factors. Although preclinical models show that various types of CVD can accelerate cancer progression, clinical studies have not determined the impact of atherosclerosis on cancer risk. OBJECTIVES: The objective of this study was to determine whether CVD, especially atherosclerotic CVD, is independently associated with incident cancer.

Sep 4, 2024 | digitalcommons.library.tmc.edu | Sebastian Bruera |Xiudong Lei |Hui Zhao |Jinoos Yazdany

OBJECTIVES: We compared the outcomes of patients with or without systemic lupus erythematosus (SLE) who were diagnosed with coronavirus disease 19 (COVID-19) and evaluated factors within patients with SLE associated with severe outcomes. METHODS: This retrospective cohort study used the deidentified Optum COVID-19 electronic health record dataset to identify patients with COVID-19 from 1/1/2020 to 31/12/2020.

Feb 14, 2023 | lupus.bmj.com | Sebastian Bruera |Xiudong Lei |Hui Zhao |Jinoos Yazdany

DiscussionTo our knowledge, this is the first study using national EHR data in the USA to describe COVID-19 outcomes among patients with SLE compared with matched controls. Patients with SLE had a statistically significant increase in rates of mortality, mechanical ventilation, hospitalisation and ICU admissions without ventilation from COVID-19 from 1 January 2020 to 31 December 2020.