Xuepeng Chen

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Extracellular stiffness regulates site-specific lung development

Jan 13, 2025 | biorxiv.org | Zhiying Liao |Junjie Lv |Dong Wang |Xuepeng Chen

AbstractExtracellular matrix (ECM) stiffness plays a crucial role in regulating cell fate and maturation, but its influence on lung development is limited known. Here we utilized stiffness-tunable gelatin methacryloyl (GelMA) hydrogels to investigate how ECM stiffness influences site-specific lung development in a stem cell-derived lung organoid model. We found increased stiffness promoted NKX2.1+ lung progenitor cells (LPCs) generation.

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