Yachen Shi

Nov 22, 2024 | onlinelibrary.wiley.com | Min Xu |Xiaoxuan Zhang |Yachen Shi |Guangjun Xi

1 Introduction Cerebral small vessel disease (CSVD) is the most common pathology behind vascular cognitive impairment and the usual dementia cause in the elderly [1-3]. Clinically accepted magnetic resonance imaging (MRI) of CSVD includes lacunar infarcts, white matter hyperintensities (WMH), cerebral microbleeds, enlarged perivascular spaces, and brain atrophy [4]. Among these, WMH is a major risk factor for incident cognitive decline in CSVD [5-7].