Yafang Zhang

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Articles

An endogenous GLP-1 circuit engages VTA GABA neurons to regulate mesolimbic dopamine neurons and attenuate cocaine seeking

Jun 24, 2024 | biorxiv.org | Riley Merkel |Nicole Hernandez |Yafang Zhang |Vannessa Weir

AbstractRecent studies show that systemic administration of a glucagon-like peptide-1 receptor (GLP-1R) agonist is sufficient to attenuate the reinstatement of cocaine-seeking behavior, an animal model of relapse. However, the neural mechanisms mediating these effects and the role of endogenous central GLP-1 signaling in cocaine seeking remain unknown.
Network pharmacology-based research on the effect of Radix Astragali on osteosarcoma and the underlying mechanism - Scientific Reports

Dec 14, 2023 | nature.com | Yafang Zhang

AbstractTo explore the anti-tumor effects of Radix Astragali on osteosarcoma and its mechanism. We analyzed the PPI network of Radix Astragali’s potential targets for treating osteosarcoma and got the hub targets. We used KM curves to screen hub targets that could prolong sarcoma patients’ survival time. We performed GO and KEGG enrichment analysis of Radix Astragali’s potential targets and predicted Radix Astragali's molecular mechanism and function in treating osteosarcoma.

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