Yafen Liang

May 29, 2024 | digitalcommons.library.tmc.edu | Wei Ruan |Xinxin Ma |Yafen Liang |Jochen Daniel Muehlschlegel

Home > UTHealth > McGovern Medical School > Journal Articles > 795 A2A, A2B, Adora2a, Adora2b, CD39, CD73, ENT1, ENT2, adenosine, hypoxia DOWNLOADS COinS

Jun 12, 2023 | nature.com | Yafen Liang

AbstractMammals have evolved to adapt to differences in oxygen availability. Although systemic oxygen homeostasis relies on respiratory and circulatory responses, cellular adaptation to hypoxia involves the transcription factor hypoxia-inducible factor (HIF). Given that many cardiovascular diseases involve some degree of systemic or local tissue hypoxia, oxygen therapy has been used liberally over many decades for the treatment of cardiovascular disorders.