Yanguo Li

Mar 15, 2024 | nature.com | Ziyang Luo |Qingfang Zheng |Shazhou Ye |Yanguo Li |Jiayi Chen |Jianing Chen | +3 more

AbstractPancreatic cancer is one of the most malignant tumor types and is characterized by high metastasis ability and a low survival rate. As a chromatin-binding protein, HMGA2 is widely overexpressed and considered an oncogene with various undefined regulatory mechanisms. Herein, we demonstrated that HMGA2 is highly expressed in pancreatic cancer tissues, mainly distributed in epithelial cells, and represents a subtype of high epithelial–mesenchymal transition.

Jan 24, 2024 | biorxiv.org | Yanguo Li |Chen Lin |Yidian Chu |Zhengyu Wei

AbstractCancer stem cells (CSCs) constitute a pivotal element within the tumor microenvironment (TME), driving the initiation and progression of cancer. However, the identification of CSCs and their underlying molecular mechanisms in laryngeal squamous cell carcinoma (LSCC) remains a formidable challenge. We employed single-cell RNA sequencing of matched primary tumor tissues, paracancerous tissues, and local lymph nodes from three LSCC patients.