Yanjin Wang

Sep 24, 2024 | onlinelibrary.wiley.com | Yanjin Wang |Chao Yu |Jianjun Yu |Fengchen Shen

1 INTRODUCTION Cisplatin is a common chemotherapy drug for cancer, but it can cause serious kidney side effects, leading to AKI and chronic kidney disease (CKD).1 The exact mechanism of cisplatin-induced nephrotoxicity is not fully understood, but it involves DNA damage, mitochondrial issues, oxidative stress, endoplasmic reticulum stress, autophagy, cell-cycle arrest, apoptosis and inflammation.1 Recent research has also highlighted the role of epigenetics in AKI pathogenesis, with various...