Yann Grobs

Dec 11, 2024 | science.org | Yann Grobs |Charlotte Romanet |Sarah-Eve Lemay |Alice Bourgeois |Pierre Voisine |Sandra Breuils-Bonnet | +7 more

Jun 1, 2024 | biorxiv.org | Sarah-Eve Lemay |Mónica S. Montesinos |Yann Grobs |Tetsuro Yokokawa

AbstractPulmonary arterial hypertension (PAH) is characterized by obliterative vascular remodeling of the small pulmonary arteries (PA) and progressive increase in pulmonary vascular resistance (PVR) leading to right ventricular (RV) failure. Although several drugs are approved for the treatment of PAH, mortality remains high. Accumulating evidence supports a pathological function of integrins in vessel remodeling, which are gaining renewed interest as drug targets.

Feb 7, 2024 | biorxiv.org | Yann Grobs |Charlotte Romanet |Alice Bourgeois |Sarah-Eve Lemay

AbstractOur study explores the previously uncharted role of ATP-citrate lyase (ACLY) in vascular remodeling within the pulmonary and coronary arteries, providing novel insights into the pathogenesis of pulmonary hypertension and coronary artery diseases. ACLY, involved in de novo lipid synthesis and histone acetylation, has emerged as a key regulator in sustaining vascular smooth muscle cell (VSMC) proliferation and survival.