Yanyang Chen

Aug 29, 2024 | science.org | Sara Martin |Melody Di Bona |Michael P. Fatt |Yanyang Chen

Editor’s summaryA high rate of chromosome mis-segregation, known as chromosomal instability, is a pervasive feature of tumors. Mis-segregated chromosomes can be encapsulated into micronuclei, abnormal nuclear structures that fuel the acquisition of complex chromosomal rearrangements upon envelope collapse. Two groups of investigators now provide mechanistic insights into micronuclei collapse and the consequences of this process for cancer (see the Perspective by Maddaluno and Settembre).