Yasuhiro Funahashi

Sep 10, 2024 | science.org | Liming Liao |Yasuhiro Funahashi |Leslie K. Ferrarelli |Ping Yang

Editor’s summaryExtranodal natural killer/T cell lymphoma (ENKTL) is treated with PEGylated asparaginase (PEG-asp), but drug resistance is common. Liao et al. found that limiting the trafficking of a glycoprotein could overcome drug resistance. Ubiquitin carboxyl-terminal hydrolase 1 (USP1) stabilized the transcription factor ATF4, which promoted CD98hc expression.

Sep 10, 2024 | science.org | Liming Liao |Yasuhiro Funahashi |Leslie K. Ferrarelli |Rijwan Uddin Ahammad

Editor’s summaryA component of the strengthened synaptic transmission that occurs in learning and memory is the growth of protrusions on neurons called dendritic spines, which requires activation of the NMDAR family of receptors in the nucleus accumbens. Funahashi et al. delineated the signaling pathway downstream of NMDARs that mediated aversive learning, which enables the identification, prediction, and avoidance of dangerous situations.

Sep 10, 2024 | science.org | Liming Liao |Yasuhiro Funahashi |Leslie K. Ferrarelli

AbstractCell type–specific gene signatures in an aged brain imply biological links to age-related disorders. SIGN UP FOR THE SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily Aging is the primary risk factor for neurodegenerative disease and causes changes, both physical and social, that can challenge an individual’s mental health.