Yazead Buhidma

Dec 6, 2023 | nature.com | Stephan Tetter |Diana Arseni |Yazead Buhidma |Sew Y. Peak-Chew |Holly J. Garringer |Kathy L Newell | +3 more

AbstractFrontotemporal lobar degeneration (FTLD) causes frontotemporal dementia (FTD), the most common form of dementia after Alzheimer’s disease, and is often also associated with motor disorders1. The pathological hallmarks of FTLD are neuronal inclusions of specific, abnormally assembled proteins2. In the majority of cases the inclusions contain amyloid filament assemblies of TAR DNA-binding protein 43 (TDP-43) or tau, with distinct filament structures characterizing different FTLD subtypes3,4.