Ye Tian

1 month ago | nature.com | Kai Zhang |Yuxuan Zhang |Ye Tian |Bin Xu |Li Lin |Zhendong Qin | +2 more

The American bullfrog (Aquarana catesbeiana) is both an economically important aquaculture species and a globally distributed invasive organism with high environmental adaptability. In this study, we present a high-quality chromosome-level genome assembly for the species, comprising 13 chromosomes with a total length of 6.32 Gb and a scaffold N50 of 691.8 Mb. Genome completeness was evaluated at 95.5% using BUSCO and 99.9% using Merqury. Repetitive sequences accounted for 79.51% of the genome. Through a combination of RNA-seq, Ab initio and homology-based gene prediction, we identified 32,382 protein-coding genes, with 98.96% of these genes functionally annotated. This chromosome-level assembly provides an important resource for future studies on the evolution, functional genomics and molecular breeding of the American bullfrog.

Apr 20, 2024 | nature.com | Xingbo Gu |Yidan Pan |Xingzhao Zhou |Xuefeidan Liu |Yan Jiang |Ye Tian

This study explores the bidirectional association between multimorbidity and falls in Chinese middle-aged and elderly adults. Participants aged 45 and above from the China Health and Retirement Longitudinal Study were included. Binary logistic regression assessed the impact of chronic conditions on fall incidence (stage I), while multinomial logistic regression examined the relationship between baseline falls and multimorbidity (stage II). The fully adjusted odds ratios (ORs) for one, two, or three or more chronic conditions were 1.34, 1.65, and 2.02, respectively. Among participants without baseline falls, 28.61% developed two or more chronic conditions during follow-up, compared to 37.4% of those with a history of falls. Fully adjusted ORs for one, two, or three or more chronic conditions in those with a history of falls were 1.21, 1.38 and 1.70, respectively. The bidirectional relationship held in sensitivity and subgroup analyses. A bidirectional relationship exists between multimorbidity and falls in Chinese middle-aged and elderly adults. Strengthening chronic condition screening and treatment in primary healthcare may reduce falls risk, and prioritizing fall prevention and intervention in daily life is recommended.