Yesu Jeon

2 weeks ago | elifesciences.org | Shengze Yao |Yesu Jeon |Barry Kesner |Jeannie Lee

eLife Assessment This valuable study addresses the potential roles of the master regulator of X chromosome inactivation, the Xist long non-coding RNA, in the regulation of autosomal genes. Using data from mouse cells, the authors propose that Xist can coat specific autosomal promoters, which in turn leads to the attenuation of their transcriptional activity. The evidence from individual genes is interesting, and the model aligns with recently published results from humans.