Yingzhe Wang

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Articles

Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition - Nature Communications

Apr 25, 2024 | nature.com | Matthew Rees |Melissa Ronan |Jennifer Roth |Yingzhe Wang |Brent A. Orr |Brian J. Abraham | +3 more

AbstractChemical discovery efforts commonly target individual protein domains. Many proteins, including the EP300/CBP histone acetyltransferases (HATs), contain several targetable domains. EP300/CBP are critical gene-regulatory targets in cancer, with existing high potency inhibitors of either the catalytic HAT domain or protein-binding bromodomain (BRD).

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