Yiqing Jin

Jan 1, 2024 | biorxiv.org | Samhan Alsolami |Arun Chandrasekaran |Yiqing Jin |Ismail Shakir

AbstractHuman naive pluripotent stem cells (nPSCs) can differentiate into extra-embryonic trophectoderm (TE), a critical step in the generation of the integrated embryo model termed blastoid. The current paradigm of blastoid generation necessitates the aggregation of dozens of nPSCs treated with multiple small molecule inhibitors, growth factors, or genetic modifications to initiate TE differentiation.