Yogesh Tak

Oct 14, 2024 | biorxiv.org | Nil Saez-Calveras |Jaime Vaquer-Alicea |Charles White |Yogesh Tak

AbstractNeurodegenerative tauopathies are characterized by the deposition of distinct fibrillar tau assemblies whose rigid core structures correlate with defined neuropathological phenotypes. Essential tremor (ET) is a progressive neurological disease associated with cognitive impairment and, in some cases, tau accumulation. Consequently, we explored the tau assembly conformation in ET patients with tau pathology using cytometry-based tau biosensor assays.