Yongjia Qiu

Sep 1, 2023 | onlinelibrary.wiley.com | Chengyuan Zhang |Feng Yuan |Yongjia Qiu

Nucleus pulposus (NP) cell apoptosis is regarded as a critical risk factor for intervertebral disc degeneration (IVDD). Melatonin exerts a protective role on NP cells. The study concentrates on the role and mechanism of lncRNA MEG3 in melatonin-mediated effects on NP cells. An in-vitro IVDD model was constructed using IL-1β on human NP cells. qRT-PCR investigated MEG3, miR-15a-5p, and PGC-1α mRNA levels in tissues and NP cells.