Yongsheng Li

2 weeks ago | nature.com | Ying Cheng |Jun Liao |Jordi Rodon |Yongsheng Li |Yun Fan |Jin Billy Li | +1 more

AbstractTrophoblast cell-surface antigen 2 (TROP2)-directed antibody–drug conjugate (ADC) is a promising anticancer agent that has shown remarkable efficacy in several malignancies. However, in lung cancer, two phase 3 trials on TROP2-ADCs in unselected patients with advanced non-small-cell lung cancer (NSCLC) have both failed. Sacituzumab tirumotecan (sac-TMT) is a novel TROP2-directed ADC.

Jan 6, 2025 | nature.com | Yongsheng Li

AbstractReactive oxygen species (ROS) is promising in cancer therapy by accelerating tumor cell death, whose therapeutic efficacy, however, is greatly limited by the hypoxia in the tumor microenvironment (TME) and the antioxidant defense. Amplification of oxidative stress has been successfully employed for tumor therapy, but the interactions between cancer cells and the other factors of TME usually lead to inadequate tumor treatments.

Dec 30, 2024 | pubs.rsc.org | Wei Zhang |Yongsheng Li |Tianyi Zheng |Ying Xie

Fluorescence Switching 2-D Sheet Structure Formed by Self-Assembly of Cruciform Aromatic Amphiphiles We report that aromatic amphiphiles based on cruciform aromatic segments self-assemble into 2-D sheet structures in aqueous environments. Notably, the aromatic amphiphile based on a pyrene unit generates fluorescence switching 2-D sheet structures. In a neutral condition, the sheets show strong excimer emission.

Sep 19, 2024 | molecular-cancer.biomedcentral.com | Yang Xiao |Yongsheng Li |Huakan Zhao

With the emergence of innovative technologies uncovering the spatiotemporal metabolomic heterogeneity within tumor-immune interplays, how to appropriately using informatic approaches for interpreting these diverse outputs has become increasingly critical. A series of algorithms have been developed for analyzing bulk metabolomics and metabolic regulomics.

Jul 31, 2024 | nature.com | Yongsheng Li

AbstractIdentification of tumor neoantigens is indispensable for the development of cancer immunotherapies. However, we are still lacking knowledge about the potential neoantigens derived from sequences outside protein-coding regions. Here, we comprehensively characterized the immunopeptidome landscape by integrating multi-omics data in acute myeloid leukemia (AML). Both canonical and non-canonical MHC-associated peptides (MAPs) in AML were identified.